What are the key results of the DENSE trial looking at the interest of MRI on the incidence of interval cancers?

New Study Reveals Dramatic Decrease in Interval Cancer Rate with MRI Screening for High-Density Breasts

A recent study published in the New England Journal in 2022 brought new insight into breast cancer screening. This randomized trial compared two methods: mammography alone and mammography with MRI when breast density was very high (type D).

Findings from the Study:

The research showed that adding MRI to mammograms for patients with very high-density breasts resulted in a remarkable decrease of approximately 84% in interval cancer rates. Interval cancer is a critical marker of prognosis, which indicates the time between two screenings when a cancer grows and is not detected.

Significance and Comparison to Previous Studies:

In France, ultrasonography is used in conjunction with mammograms, but no studies have proven an impact on interval cancer rates. This trial marks the first time an imaging modality has demonstrated such a significant impact.


The results suggest that MRI screening could be highly beneficial for those with very high-density breasts, improving early detection and potentially leading to better outcomes. More research will be needed to determine the long-term implications and potential challenges of implementing this approach in clinical settings.

  • April 23, 2024