Focus

Innovative Strategies in Breast Cancer: AI Insights and Global Health Equity

Breast cancer has established itself as a leader in cancer research and treatment, particularly through its emphasis on early intervention strategies. The latest BCU conference focused on promoting women's health via a multidisciplinary approach, building upon themes introduced at the 2024 conference. This commitment to integrating diverse medical disciplines underscores the importance of collaborative efforts in advancing patient outcomes and fostering innovation in breast cancer care.

AI and CT Scans for Assessing Biological Age

Current research is exploring the use of artificial intelligence (AI) to determine a patient's biological age by analyzing data from CT scans - a concept that goes beyond chronological age. Perry J. PICKHARDT's work leads him to consider the vast amount of data present in CT scans beyond signs of metastatic disease or treatment response-fat, muscle, calcium deposits, and the structure of organs such as the liver. While we don't typically use all of this information during routine screenings, it holds significant potential for understanding a patient's overall health and risk factors. The ultimate goal is to create a system that accurately stratifies patients into risk categories based on their unique metabolic profiles.

A New Era in Cancer Treatment: Recent Advances in Progress

Cancer treatment has always been a journey of evolution, with gradual improvements over time. However, the last couple of years have witnessed a remarkable shift. This isn't just incremental improvement; we're seeing "little spits of massive advance," as Georgia DEMETRIOU describes it. The introduction of new therapies like CKD 4/6 inhibitors in the adjuvant setting exemplifies this leap forward. 2 drugs within this category have shown promising benefits, marking a turning point in treatment strategies. Due to its high profile, extensive research efforts, and strong patient advocacy, breast cancer serves as a model for other cancers, demonstrating the way forward in improving cancer care and outcomes.

Bridging Cancer Care Gaps: AROME's Mission in the Mediterranean

AROME is an association dedicated to supporting oncologists from the Mediterranean region for over a decade. Jospeph GLIGOROV is the co-founder and President of this organization. It has been shown recently that the incidence of advanced-stage cancers is more prevalent in LMIC (Low Middle Income Countries) compared to HIC (High Income Countries). This disparity indicates that treatment needs may not be identical across regions. While both rich and poor countries require essential treatments for curable diseases, LMIC often struggle with more metastatic diseases and limited access to expensive drugs beneficial in such case.

Molecular Imaging: At the Forefront of Innovation

Molecular imaging, such as positron emission tomography (PET), is increasingly used as biomarker to predict and assess treatment response in breast cancer. Willy VANGU explain the potential prognostic value of dual biomarkers in ER positive breast cancer patients. To ensure effective patient care, potential responders to HER-targeted therapy need to be identified. Radionuclide molecular imaging can be a key asset for the detection of overexpression of EGFR (Epidermal Growth Factor Receptor) family members. To complete this interview, you can enjoy the talk of Eric ZERBIB on preoperative assessment with FDG PET Scan in the Session section.

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Breast cancer dynamics: Molecular signature, Radiotherapy and Nuclear Medicine

It's summertime, and we're about to take you on an exciting journey through the latest advances in breast cancer treatment in a truly multidisciplinary way. We hope you'll enjoy the ride. Stay tuned and have a safe trip!

Decoding biomarkers for more personalized care

Biomarkers in breast cancer management serves as crucial indicators for diagnosis, prognosis and treatment response. They can identify patients who are likely to benefit from specific therapies and monitor treatment efficacy. Advances in biomarkers research through next-generation sequencing are improving precision medicine. Simon NAYLER tells us how this is enabling tailored treatment strategies to improve patient outcomes. We invite you to go deeper in the session section.

Molecular Imaging: at the forefront of innovation

Molecular imaging, such as positron emission tomography (PET), is increasingly used as biomarker to predict and assess treatment response in breast cancer.  Willy VANGU explain the potential prognostic value of dual biomarkers in ER positive breast cancer patients. To ensure effective patient care, potential responders to HER-targeted therapy need to be identified. Radionuclide molecular imaging can be a key asset for the detection of overexpression of EGFR (Epidermal Growth Factor Receptor) family members. To complete this interview, you can enjoy the talk of Eric ZERBIB on preoperative assessment with FDG PET Scan in the Session section.

Radiotherapy in early breast cancer

The significance of radiation therapy following neoadjuvant systemic therapy is a topic of ongoing discussion, specifically concerning regional nodal irradiation in patients achieving a complete response. We invite you to go further with Yazid BELKACEMI our next BCU Co-president. He will discuss the number of fractions for delivering a radiation therapy boost which is a critical aspect from a technical perspective, especially when using simultaneous integrated boost and the shift towards moderate hypofractionation. You’ll be able to go further with a comprehensive presentation on ongoing trials in early breast cancer by Sithembile NGIDI in the session section.

Dr Jean-Philippe MINART, Cannes, France