Focus

Redefining Breast Cancer Care: A Multidisciplinary Transformation

This FOCUS explores the latest advancements in cancer care across various disciplines. From targeted therapies that are transforming breast cancer treatment, to the transformative impact of AI on pathology, screening and surgical techniques, these presentations explore the latest research and clinical practices. Discover how these innovations are paving the way for a future of more precise, personalised and effective cancer management.

Trageted Therapies : A Deep Dive into the Latest Advances

Targeted therapies are changing breast cancer treatment, particularly in HER2-positive disease. This presentation explores the evolving landscape of these agents, focusing on their efficacy and mechanisms of action. Hassan Ghazal will discuss the impact of novel therapies like trastuzumab deruxtecan (TDXD) and other emerging targeted therapies across various treatment lines. Join us as we analyze the scientific basis for these advancements and their implications for patient outcomes in breast cancer.

Click on the link  to read the extensive resume of Hassan GHAZAL 

AI: Reshaping Pathology

Artificial intelligence (AI) is revolutionizing pathology, particularly in cancer diagnosis. While still emerging, AI solutions are already improving accuracy and consistency. Aaron HAN explains how by digitizing slides and analyzing them at a pixel level, AI can reveal subtle details previously missed by traditional methods. This empowers pathologists with deeper insights into diseases like breast and prostate cancer. AI's ability to analyze complex genetic networks and environmental factors is also transforming cancer research. By learning and adapting to vast datasets, AI helps uncover hidden patterns and relationships, paving the way for personalized treatments tailored to each patient's unique needs.

Bridging Boundaries: The Evolving Landscape of Breast Surgery

Surgery stands as a cornerstone in breast cancer treatment, encompassing procedures like lumpectomy and mastectomy. Beyond tumor removal, surgeons like Dr. Yazan Masannat are at the forefront of integrating reconstructive techniques, offering patients the option to rebuild their breasts after surgery. This often involves a collaborative effort with radiologists, who utilize imaging to guide surgical planning and ensure optimal outcomes. The lines between specialties are becoming increasingly blurred, reflecting the multidisciplinary nature of modern healthcare.

Cascade: AI for Enhanced Lung Cancer Screening

The Cascade research project, led by Professor Marie-Pierre Revel, focuses on leveraging artificial intelligence to improve lung cancer screening, especially for women. The project recognizes the increasing incidence of lung cancer among European women and aims to enhance the accuracy and efficiency of existing screening methods. Cascade researchers are exploring how deep learning algorithms can act as a reliable second reader in conjunction with low-dose computed tomography (LDCT) scans, potentially streamlining the process and improving detection rates.

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Innovative Strategies in Breast Cancer: AI Insights and Global Health Equity

Breast cancer has established itself as a leader in cancer research and treatment, particularly through its emphasis on early intervention strategies. The latest BCU conference focused on promoting women's health via a multidisciplinary approach, building upon themes introduced at the 2024 conference. This commitment to integrating diverse medical disciplines underscores the importance of collaborative efforts in advancing patient outcomes and fostering innovation in breast cancer care.

AI and CT Scans for Assessing Biological Age

Current research is exploring the use of artificial intelligence (AI) to determine a patient's biological age by analyzing data from CT scans - a concept that goes beyond chronological age. Perry J. PICKHARDT's work leads him to consider the vast amount of data present in CT scans beyond signs of metastatic disease or treatment response-fat, muscle, calcium deposits, and the structure of organs such as the liver. While we don't typically use all of this information during routine screenings, it holds significant potential for understanding a patient's overall health and risk factors. The ultimate goal is to create a system that accurately stratifies patients into risk categories based on their unique metabolic profiles.

Perry J. PICKHARDT , Madison, USA
Dr. Perry J. Pickhardt is currently a Professor of Radiology and Chief of Gastrointestinal Imaging at the University of Wisconsin School of Medicine & Public Health.

A New Era in Cancer Treatment: Recent Advances in Progress

Cancer treatment has always been a journey of evolution, with gradual improvements over time. However, the last couple of years have witnessed a remarkable shift. This isn't just incremental improvement; we're seeing "little spits of massive advance," as Georgia DEMETRIOU describes it. The introduction of new therapies like CKD 4/6 inhibitors in the adjuvant setting exemplifies this leap forward. 2 drugs within this category have shown promising benefits, marking a turning point in treatment strategies. Due to its high profile, extensive research efforts, and strong patient advocacy, breast cancer serves as a model for other cancers, demonstrating the way forward in improving cancer care and outcomes.

Bridging Cancer Care Gaps: AROME's Mission in the Mediterranean

AROME is an association dedicated to supporting oncologists from the Mediterranean region for over a decade. Jospeph GLIGOROV is the co-founder and President of this organization. It has been shown recently that the incidence of advanced-stage cancers is more prevalent in LMIC (Low Middle Income Countries) compared to HIC (High Income Countries). This disparity indicates that treatment needs may not be identical across regions. While both rich and poor countries require essential treatments for curable diseases, LMIC often struggle with more metastatic diseases and limited access to expensive drugs beneficial in such case.


Joseph GLIGOROV
MD, PHD Medical Oncologist, Paris, France
Dr Jean-Philippe MINART, Cannes, France